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Ketamine News and Research

Coverage in popular media

Ketamine Therapy Is Going Mainstream. Are We Ready?

The mind-altering drug has been shown to help people suffering from anxiety and depression. But how it helps, who it will serve, and who will profit are open questions… I didn’t want to drink alcohol, or even coffee, out of a fear that the feeling would abandon me; I dread being thrown back into my ordinary mind. The feeling lasted a little more than two weeks, and then it went away. The memory of what it had felt like lingered a bit longer, and then it went away, too. 

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NYT - I Was Paralyzed by Severe Depression. Then Came Ketamine.

When my brother got his first pair of glasses, he marveled that he could see individual leaves on trees. Ketamine felt a lot like that. To be in awe of simple pleasures felt like reason enough to live, and I was overcome with a quiet revelation: this is what it means to be content. I began contemplating a return to school. In May 2021, 15 years after dropping out of high school, five years after beginning ketamine treatment, I graduated from college.

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Ketamine for depression: What it feels like and who it can help

Ketamine treatment, in general, is for people suffering from serious mental illness who have tried other medications with little or no relief. It has been most widely studied in people with treatment-resistant depression and acute suicidality. It may also benefit patients with conditions such as PTSD, OCD, bipolar depression, anxiety and eating disorders. People with certain conditions such as psychosis generally are not candidates for therapeutic ketamine.

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More Than Just a Trip: Why Does Ketamine Work for Depression When Nothing Else Does?

Even though depression is a common and debilitating mental illness, the last groundbreaking medication released for it was Prozac, approved in 1987. Throughout the last 20 years, though, research scientists have discovered that ketamine, a common anesthetic and, at times, a recreational drug, is a rapid and effective medication for treatment-resistant depression. As we’re learning deeper about why, we turn specifically to its dissociative effects for clues….. 
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Ketamine Infusions Show Growing Promise for Treating Anxiety and Depression Growing body of studies indicate ketamine treatment for mental health could become more widely accessible in the coming years.

Ketamine, a substance traditionally used as an anesthetic, has been found to be beneficial for treating mental health issues including depression and anxiety.

A new study published in the Journal of Clinical Pyschiatry revealed that people who received intravenous ketamine treatments showed clear improvement in their anxiety, depression, and suicidal ideation symptoms.

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Ketamine in popular news media

  • Yale Medicine Video: Ketamine and Depression:How it works

  • Yale Medicine: How Ketamine Drug Helps with Depression

  • The Washington Post: Ketamine for Depression: What it Feels Like and Who it Can Help

  • The New Yorker: Ketamine Therapy Is Going Mainstream. Are We Ready?

  • Elemental: Ketamine Is Revealing a New Understanding of Depression and the Brain

  • Psychology Today: IV Ketamine for Treatment-Resistant Depression

  • Gizmodo: More Than Just a Trip: Why Does Ketamine Work for Depression When Nothing Else Does?

  • The New York Times: I Was Paralyzed by Severe Depression. Then Came Ketamine.

Societal consensus statements

  • 2022 Updated US Guidelines for Treating MDD, Annals of Internal Medicine 2022

  • Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation, The American Journal of Psychiatry 2021

  • A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders,  JAMA Psychiatry 2017

  • Intravenous Ketamine for Adults With Treatment-Resistant Depression or Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines, The Canadian Journal of Psychiatry 2021

Ketamine infusion therapy and depression (Systematic Reviews and Meta-Analyses)

  • International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators, Nature 2022

  • Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis, Journal of Psychiatric Research 2022

  • Efficacy of ketamine for major depressive episodes at 2, 4, and 6-weeks post-treatment: A meta-analysis, Psychopharmacology 2021

  • Neurocognitive effects of ketamine and esketamine for Treatment-Resistant Major Depressive Disorder: A systematic review, Harvard Review of Psychiatry 2021

  • Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis, Journal of Affective Disorders 2021

  • Registered clinical trials investigating ketamine for psychiatric disorders, Journal of Psychiatric Research 2020

  • The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with Major Depressive Disorder: A systematic review, Journal of Affect Disorders 2020

  • Leveraging neuroplasticity to enhance adaptive learning: The potential for synergistic somatic-behavioral treatment combinations to improve clinical outcomes in Depression, Biological Psychiatry 2019

Ketamine therapy and depression

  • Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial, Psychotherapy and Psychosomatics 2021

  • Early symptomatic improvements as a predictor of response to repeated-dose intravenous ketamine, Progress in Neuro-Psychopharmacology and Biological Psychiatry 2021

  • Cardiovascular effects of repeated subanaesthetic ketamine infusion in depression, Journal of Psychopharmacology 2020

  • Antidepressant and Neurocognitive Effects of Serial Ketamine Administration Versus ECT in Depressed Patients, Journal of Psychiatric Research 2020

  • Ketamine Normalizes Subgenual Cingulate Cortex Hyper-Activity in Depression, Neuropsychopharmacology 2020

  • Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD), Nature 2018

  • Maintenance Ketamine Therapy for Treatment-Resistant Depression, Journal of Clinical Psychopharmacology 2018

Depression and antidepressants

  • National Institute of Mental Health: Review of Depression

  • Efficacy and Effectiveness of Antidepressants: Current Status of Research

Ketamine drug properties and history

  • Ketamine Wikipedia Entry

  • Ketamine Manufacturer Data Sheet,  Pfizer

  • W.H.O. Fact Sheet, World Health Organization

  • Ketamine – 50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms, Pharmacological Reports

Ketamine other uses

  • Bipolar Disorder: Ketamine for bipolar depression: a systematic review, International Journal of Neuropsychopharmacology 2021

  • Substance Abuse Disorder: Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review, Frontiers in Psychiatry 2018

  • PTSD: Evidence for the beneficial effect of ketamine in the treatment of patients with post-traumatic stress disorder: A systematic review and meta-analysis.

    Journal of Cerebral Blood Flow & Metabolism, 2022

  • Suicidal Thoughts: Ketamine for suicidal ideation in adults with psychiatric disorders: A systemic review and meta-analysis of treatment trials Au and Nz Journal of Psychiatry 2019

  • Anxiety Disorder: Efficacy and safety of ketamine in the management of anxiety and anxiety spectrum disorders: a review of the literature, CNS Spectrums 2019

  • Pain disorders: Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management, Regional Anesthesia and Pain Medicine 2018

 

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